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赵宝华

发布时间:2017-04-18


赵宝华

博士

教授

博士研究生导师

联系电话:0311-80787578

电子邮件:zhaobaohua@mail.hebtu.edu.cn

所属专业:生物化学与分子生物学、微生物学

学习经历:

2017/06 – 2017/09,新加坡南洋理工大学,教育学院,高级访问学者;

2009/03– 2009/09,美国路易斯安那州立大学,兽医学院,高级访问学者;

2001/12 – 2004/03,williamhill中国官方网站,williamhill中国官方网站,博士后出站;

1998/09 – 2001/07,解放军军需大学,军事兽医研究所,获得农学博士学位;

1990/09 – 1993/07,williamhill中国官方网站,生物系,获得理学硕士学位;

1986/09 – 1990/07,williamhill中国官方网站,生物系,获得理学学士学位;

参加学术团体或学术任职:

河北省生物化学与分子生物学学会理事

河北省畜牧兽医学会检验检疫分会副会长

河北省科技创新研究会副理事长

主要教学科研工作:

主要研究方向:动物病原微生物分子致病机制及其防控。采用现代微生物学、生物化学与分子生物学、分子免疫学等手段研究家畜家禽和主要水生动物等重要病原微生物的分子致病机理和基因工程疫苗。已完成国家自然科学基金项目2项;正在主持河北省科技厅揭榜挂帅榜单项目和河北省科技厅农业科技成果转化资金项目各1项。在Journal of Nanobiotechnology,Vaccine,Journal of Immunology, Anal Bioanal Chem,Hepato-Gastroenterology,Antiviralresearch, European journal of phamacology, CellularImmunology, Virus Gene,Brain Research Bulletin,微生物学报,中国兽医学报等杂志共发表学术论文100余篇,获河北省科技进步三等奖2项。主持《微生物学》省级课程思政示范课程,作为副主编编写《微生物学教程》和《免疫学》教材两部,发表教学改革论文20余篇,指导的本科生获全国“挑战杯”大学生科技创新大赛二等奖和三等奖各1项,作为主要参加人员荣获国家级研究生优秀成果奖1项,河北省优秀教学成果二等奖2项,获河北省职业道德先进个人。

承担的主要科研项目:

1. 低GI益生菌发酵乳技术规程及中试生产线的建立,河北省农业科技成果转化资金项目,2024-2025

2. 河北省冷水鱼绿色高效养殖技术集成与示范,编号 21326703D,河北省科技厅-农业高质量发展关键共性技术攻关专项,2021-2023

3. 虹鳟鱼健康养殖及全程质量控制技术集成与示范,编号17226701D,河北省科技厅-农业关键共性技术攻关专项,2017-2019

4. 猪重要疫病诊断防控及特色养殖关键技术研究与示范,编号13226603D,河北省科技支撑计划,2013-2015;

5. G17-PE38KDEL胃癌靶向生物学效应研究,编号C2011205115,河北省自然科学基金,2011-2013;

6. 山区奶牛养殖主要疫病防控关键技术研究与开发,编号11230405D-2,河北省科技支撑计划,2011-2013;

7. 绵羊肺炎支原体Y98主要外膜抗原蛋白筛选与功能鉴定,编号30871880,国家自然科学基金,2009-2011;

8. 抗产气荚膜梭菌主要致死性毒素ScFv抗体库的构建,编号C2009000290,河北省自然科学基金,2011-2013。

发表的部分研究论文:

[1] Jinglin Xu , Dongxue Li , Lin Kang,Tingting Liu, Jing Huang, Jiaxin Li, Jing Lv, Jing Wang, Shan Gao, Yanwei Li,Bing Yuan, Baohua Zhao(责任作者)., Jinglin Wang and Wenwen Xin. Systematic evaluation ofmembrane-camoufaged nanoparticles in neutralizing Clostridium perfringensε-toxin,Journal of Nanobiotechnology,2023, 21(95):1-19

[2] Jing Huang, Baohua Zhao(共第一作者),, Tingting Liu, Lin Kang , Jiaxin Li , Zishuo Guo, Ming Chen ,Shan Gao , Jing Wang, Yanwei Li, Jinglin Wang, and Wenwen Xin. Statins asPotential Preventative Treatment of ETX and Multiple Pore-Forming Toxin-InducedDiseases, International journal of molecular sciences, 2023, 24:1-19

[3] Tingting Liu, Lin Kang, Jinglin Xu,Jing Wang, Shan Gao, Yanwei Li, Jiaxin Li,Yuan Yuan, Bing Yuan, Jinglin Wang, BaohuaZhao(责任作者) and Wenwen Xin. PVBase: A MALDI-TOFMS Database for Fast Identification and Characterization of PotentiallyPathogenic Vibrio Species From Multiple Regions of China, Frontiers inMicrobiology, 2022,13: 872825-872836  

[4] Han Han, Chongwen Wang, XingshengYang, Shuai Zheng, Xiaodan Cheng,Zhenzhen Liu, Baohua Zhao(责任作者) , Rui Xiao. Rapid field determination of SARS-CoV-2 by acolorimetric and fluorescent dual-functional lateral flow immunoassay biosensor,Sensors and Actuators B: Chemical, 2022,351:: 130897-130906

[5] Baohua Zhao, Zhiying Jin, Yunzhou Yu, Yue Li, Jing Wang, Wei Wan, Chenyi Hu, Xiaoyang Li, Yanwei Li, Wenwen Xin,Lin Kang, Hao Yang, Jinglin Wang, and Shan Gao. A Thermostable DissolvingMicroneedle Vaccine with Recombinant Protein of Botulinum Neurotoxin Serotype A,Toxins, 2022, 14:881-892

[6] M. Muhammad, J. Bai, A. J. Alhassan, H.Sule, J. Ju , B. Zhao(责任作者), and D. Liu. Significanceof Glutamate Racemase for the Viability and Cell Wall Integrity ofStreptococcus iniae, Biochemistry, 2020, 85(2):248-256

[7] Shanshan Gao, Na Zhao, SaidAmer,Mingming Qian, Mengxi Lv, Yuliang Zhao, Xin Su, Jieying Cao, HongxuanHe,Baohua Zhao(责任作者). Protective efficacy of PLGA microspheres loaded with divalentDNAvaccine encoding ompA gene of aeromonas veronii and hly gene ofaeromonashydrophila in mice [J]. Vaccine, 2013, 40(11): 1132-1139

[8] Yanqing Bian, Xiujun Zhao, Menghu Li,Shaohua Zeng, Baohua Zhao(责任作者). Various roles ofastrocytes during recovery from repeatedexposure to different doses oflipopolysaccharide[J]. Behav Brain Res, 2013,253:253-61

[9] Yanqing Bian, Zhuo Pan, Ziyuan Hou,CuiHuang, Wei Li, Baohua Zhao(责任作者). Learning, memory,and glial cell changes following recovery fromchronic unpredictable stress [J].Brain Research Bulletin, 2012, 88(5):471-476.

[10] Fengyang Lei, Baohua Zhao(共第一作者),Rizwanul Haque, Xiaofang Xiong,Lynn Budgeon, Neil D. Christensen, Yuzhang Wu,Jianxun Song. In vivo programmingof tumor antigen-specific T lymphocytes frompluripotent stem cells to promotecancer immunosurveillance [J]. Cancer Research, 2011, 71(14): 4742-4747.

[11] Zhi-Hui Zheng, Yi Yang , Xin-HuaLu,Hua Zhang, Xiao-Xi Shui , Chen Liu, Xiao-Bo He, Qin Jiang, Bao-Hua Zhao(共责任作者),Shu-Yi Si. Mycophenolic acid induces adipocyte-like differentiationandreversal of malignancy of breast cancer cells partly through PPARγ[J].Europeanjournal of pharmacology, 2011, 658(1):1-8.

[12] Xiaoxi Shui, Xinhua Lu, Yan Gao,ChenLiu, Fengzhi Ren, Qin Jiang, Hua Zhang, Baohua Zhao(共责任作者),Zhihui Zheng. A mammalian two-hybrid system-based assay forsmall-molecular HIVfusion inhibitors targeting gp41[J]. Antiviral research,2011, 90(1): 54-63.

[13] Zhi-Hui Zheng, Xin-Hua Lu, HuaZhang,Guo-Ping Lv, Jian-Gong He, Bao-Hua Zhao(共责任作者),Shu-Yi Si.Impacts of different promoters on the mammalian one-hybrid assay fordetectingnuclear receptor agonists[J]. Anal Bioanal Chem, 2010,396(5):1721–1730 .

[14] Jie Song, Di Shen, Jie Cui,BaohuaZhao(责任作者). Accelerated evolution of PRRSV duringrecent outbreaks in China[J]. Virus Gene, 2010, 41(2):241–245.

[15] Baohua Zhao(第一作者), AihuaSong, Rizwanul Haque, Fengyang Lei, Lauren Weiler, XiaofangXiong, Yuzhang Wu,Michael Croft, Jianxun Song. Cooperation between moleculartargets ofcostimulation in promoting T cell persistence and tumor regression[J].Journal of Immunology, 2009, 182(11): 6744-6752.

教学、科研获奖(含各种荣誉称号):

1. 仔猪腹泻基因工程菌株的构建及其免疫原性研究,赵宝华、边艳青、杨英伟、田莉瑛、柏佳宁、宋杰、胡奕,河北省科技进步奖,三等奖,2011;

2. 海水工厂化养殖推广,申红旗、赵宝华、李全振、曹杰英、杨振才,河北省科技进步奖,三等奖,2008。

3. 《教学科研学科一体化,生物学专业人才培养体系改革与实践》,刘敬泽、郭毅、赵宝华、周春江、王翠琴,河北省教学成果二等奖,2017

4. 《一引领三保障五机制一一地方院校生物学研究生培养体系构建与实践》,2022年高等教育(研究生)国家级教学成果二等奖,排名第10。


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